This paper will introduce process-oriented guided inquiry learning (POGIL) in entrepreneurship, and model a POGIL activity. POGIL has been developed and validated over the last fifteen years, primarily in chemistry education. In POGIL, teams of learners (typically 3-5) work on scripted inquiry activities and investigations designed to help them construct their own knowledge, often by modeling the original processes of discovery and research. Teams follow processes with specific roles, steps, and reports that encourage individual responsibility and meta-cognition, and should help prepare students for E-Teams. Multiple studies have examined the effectiveness of POGIL, and generally find that it significantly improves student performance, particularly for average and below-average students.